Api-Life VAR is the best miteacide composed of all natural essential oils you can use against Varroa Mites. It is up to 95% effective while leaving minimal residue. Treat each colony by breaking 1 wafer into 4 pieces and placing around the brood nest. Leave 7 to 10 days and replace with another wafer and after 7 to 10 days replace for a 3rd time. This will complete the treatment. Treatment most effective at average daytime temperatures of 65°.